For Army Sgt. Shaun Castle, the Army was becoming a career.
As a military policeman in the early 2000s, Castle had some key war-zone assignments to Kosovo, Macedonia and the Middle East that were tracking toward a bright future in the service.
But in 2005, Shaun suffered a spine injury that eventually ended his Army career. And while he recovered enough to serve as a police officer in Alabama, his prior-service injury worsened and he had to leave the force, losing the use of his legs.
Undaunted, Shaun focused on getting a college degree and earned a place on the roster of the University of Alabama wheelchair basketball team where he’s also a member of the 2020 Paralympic Games development team.
In 2012, after standing under the Paralympic banners of the Birmingham-based Lakeshore Foundation, Castle began training six days per week – hard work that has paid dividends for the now collegiate and professional sports star who plays for the University of Alabama’s men’s wheelchair basketball team and the USA Developmental team. Castle also has played professional wheelchair basketball in Lyon, France, and is a Paralympic hopeful for the 2020 Games in Tokyo, Japan. (Photo from Shaun Castle)
An advocate for Paralyzed Veterans of America and the Lakeshore Foundation, Castle has participated in numerous radio spots and other promotions in which he’s known for making mundane topics – like MREs (meals ready to eat) – sound interesting. In 2016, Castle pioneered the construction of an arena dedicated solely to wheelchair basketball at the University of Alabama. (Photo from Shaun Castle)
I wish every veteran could get a makeover from the Queer Eye Fab Five — and before you reach for your beers and bullets, hear me out: the military teaches us to suck it up and prepares us for the worst conditions on earth…and that gruffness becomes the standard of living even after we get out.
It doesn’t have to be that way. Not for us. Not for our families.
Just ask Brandonn Mixon, U.S. Army veteran and co-founder of Veterans Community Project, an organization that provides housing and walk-in services for service members in order to end veteran homelessness. Mixon literally builds houses for homeless vets.
The Queer Eye team decided to return the favor, helping Mixon finish his own home, upgrade his professional look, and learn to process his service-connected Traumatic Brain Injury. In spite of all the good Mixon does for his brothers and sisters in arms, Mixon confided to Karamo Brown that he feels like he’s failing in life.
“Who told you that you’re failing?” Brown pressed.
Returning to civilian life after years of service is bittersweet. Having more time with family is a blessing, but after getting used to an intense job that comes with lots of rules and regulations, it’s unnerving for some to suddenly have the freedom to do, well, anything! Starting a new career can be intimidating, especially for those who joined the military straight out of high school.
Luckily, it doesn’t have to be. There are plenty of employers who go out of their way to hire veterans and current service members! These are just a few of the awesome jobs that put your military expertise to good use.
1. Customer Service Representative
Median Annual Salary: ,300*
The Forecast: The BLS projects 5-9% job growth through 2026.
What They Do: Customer service reps chat with customers and potential new ones to explain available products and services. They also often help troubleshoot products and solve problems, all while calming down frustrated customers. Military-grade problem solving is a big help for this one!
What You’ll Need: High school diploma plus training on the job and basic computer skills. Communication skills are a must, too! Entry-level positions don’t pay much, but many veterans climb the ladder quickly into more lucrative leading roles.
2. CDL Driver/Operator
Median Annual Salary: ,340*
The Forecast: The BLS projects 6% job growth through 2026.
What They Do: Always a popular choice for veterans, truck driving is a no-brainer if you need a job fast. Companies are almost always hiring, and it’s an ideal job for someone strong who’s used to working long hours.
What You’ll Need: High school diploma or GED and a commercial driver’s license, or CDL. For a boost in pay, consider getting a Class A CDL to allow you to drive big rigs.
3. Sales Account Representative
Median Annual Salary:
Technical/Scientific Products: ,980
Wholesale and Manufacturing: ,140
The Forecast: The BLS projects 5-14% job growth through 2026.
What They Do: Sales reps convince new customers to purchase products or sign up for services. Sometimes this is on the consumer level, but it can also be between businesses and to large organizations. Highly motivated, performance-driven individuals will thrive in this field.
What You’ll Need: High school diploma or GED, sales experience a plus. Some employers train new sales associates, but the most successful reps are naturally persuasive and charismatic.
4. Automotive Technician/Mechanic
Median Annual Salary: ,470*
The Forecast: The BLS projects 6% job growth through 2026.
What They Do: Technicians and mechanics examine the inner workings of automobiles and make any necessary repairs. You don’t have to be an engineer, but you do need to be good at problem-solving and decoding repair manuals.
What You’ll Need: Formal training and industry certification is usually required. In some cases, relevant military training is enough.
5. Security Systems Technician
Median Annual Salary: ,330*
The Forecast: The BLS projects 10-14% growth through 2026.
What They Do: If repairing, programing, and installing important security and fire alarm equipment sounds like your cup of tea, becoming a security systems tech is a great choice. They keep these systems running smoothly and make sure they comply with codes to keep everyone in the building safe.
What You’ll Need: Relevant military training or on-the-job experience may already have you covered. If not, vocational school will get the job done.
6. Construction Technician
Median Annual Salary: ,480
The Forecast: The BLS projects 18% growth through 2026.
What They Do: In between a construction manager and civil engineer, construction techs wear many hats. Job responsibilities may include managing projects, scheduling inspections, and estimating build expenses.
What You’ll Need: Construction technicians can often learn on the job and work their way up, but you can also get an associate’s degree in construction technology.
The Forecast: The BLS projects 5-9% job growth through 2026.
What They Do: It’s a long title, but this type of first-line supervisor is really just an expert mechanic in charge of other mechanics.
What You’ll Need: A high school diploma or GED, plus relevant experience. In many cases, military training will already make you a strong candidate.
1. Operations Manager
Median Annual Salary: ,310*
The Forecast: The BLS projects 5-9% job growth through 2026.
What They Do: The specifics vary widely by industry, but operations managers are in charge of keeping large-scale business operations running smoothly. Their goal is to coordinate between multiple departments to maximize efficiency.
What You’ll Need: A bachelor’s degree and experience in management is usually required, but military leadership roles will give you a big leg up.
2. Computer Information Systems Manager
Median Annual Salary: 5,800
The Forecast: The BLS projects 10-14% job growth through 2026
What They Do: For the computer geeks out there, computer information systems management is an excellent option. These managers are responsible for assessing the digital activity of an entire company and deciding what technological improvements could help them meet their goals.
What You’ll Need: A bachelor’s degree or graduate degree in computer or information science. It’s also critical to be up to date on all the latest technology.
The Forecast: The BLS projects 2-4% job growth through 2026.
What They Do: This type of first-line supervisor manages offices. Companies that have many employees or departments need someone to manage the office, which is where the supervisor comes in to oversee administrative and clerical workers.
What You’ll Need: While it’s possible to work your way up to this position, it commonly requires an associate’s or bachelor’s degree.
Median Annual Salary: ,720*
The Forecast: The BLS projects 9% job growth through 2026.
What They Do: Electricians handle anything electrical. Installing wiring, repairing fixtures and outlets, troubleshooting outages, and making sure electrical systems are up to code are just a few of the responsibilities of an electrician.
What You’ll Need: If you don’t have military training as an electrician, a vocational school is the way to go. You’ll also need to be licensed in your state before you start job searching.
5. Aircraft/Aviation Technician
Median Annual Salary: ,270
The Forecast: The BLS projects 5% job growth through 2026.
What They Do: Aviation techs are the people who keep airplanes from falling out of the sky. They maintain aircraft, diagnose and repair mechanical problems, and assess numerous complicated pieces of machinery.
What You’ll Need: Military vocational training will do the trick, but if you trained in a different area don’t sweat it. You’ll need to earn a mechanic’s certificate with an airframe rating, power plant rating, or both.
Team Rubicon launched what they call “Operation Nirman,” in mid-March 2016. The mission is to rebuild a school and restore services in areas of Central Nepal damaged by last year’s devastating 7.8 magnitude earthquake. Team Rubicon members from the U.S., United Kingdom, Australia, Canada, and Germany deployed to assist with Nirman. They will also receive help from the Prince of Wales.
Prince Harry is in the country on an official tour to see the many initiatives supporting the people of Nepal in the wake of the earthquake’s widespread destruction. After his official tour ends, the prince, himself an Afghan War veteran, will remain in Nepal with Team Rubicon on their relief efforts.
The 31-year-old royal is known for his dedication to veterans from all countries and his support for tackling the challenges they face. He runs the Endeavor Fund with his brother, Prince William and his wife, Princess Catherine. Endeavor Fund is a UK-based nonprofit to help service members overcome these challenges while “keeping Armed Forces issues in the public consciousness.”
Prince Harry will be embedded with a group of Team Rubicon volunteers in a remote village to help with the reconstruction of the new school. The team will trek into the mountains of Central Nepal with all the necessary equipment to assist the local community in repairing and rebuilding their school.
Since the earthquake struck, students have been taking their classes in makeshift classrooms made of poles, tarps, and tin sheets. These temporary facilities will provide little defense against the difficult weather conditions in the rainy season to come.
“The people I have met and the beauty of this country make it very hard to leave,” Prince Harry said. “The team I’m joining will be working with the community to rebuild a school damaged in the earthquake. I’m so grateful to have this opportunity to do my small bit to help.”
Team Rubicon UK was formed in response to the Nepal earthquake. General Sir Nick Parker, former Commander in Chief of the UK Land Forces and now Chairman of Team Rubicon UK, called for veterans in the United Kingdom to volunteer their time and skills in the immediate aftermath. A team quickly joined their Team Rubicon USA counterparts to provide medical aid, search and rescue support, and translation assistance in several remote regions of Nepal.
Former British Army gunner Christopher Lyon cleans up a local playground in Shermathang, Sinduhupalchok. (Team Rubicon photo)
By the end of the 2015, Team Rubicon UK responded to calls for help after floods in Cumbria and Yorkshire, as well as undertaking rebuilding projects in Nepal and the Philippines.
The US Marine Corps wants to add another title in front of some of its officers’ ranks: Doctor.
The service is establishing two pilot programs to offer qualified majors through lieutenant colonels with a doctorate-level education on the Corps’ dime, as long as they agree to stay in the service for an additional six years.
The program’s goal is to develop a “cohort of strategic thinkers and technical leaders capable of applying substantive knowledge, directing original research, and leveraging relationships with industry and elements of national security … to achieve the innovative thinking desired by the Marine Corps,” according to the announcement August 3.
“Uniformed doctorates provide the Marine Corps deployable, highly-skilled manpower in support of senior leader decision-making as well as helping generate national, defense, and service strategies in an increasingly complex world.”
The pilot will likely be competitive, since only four officers will ultimately be picked; two will be required to pursue a doctorate in strategic affairs, while two others will be required to attend a doctoral program with a technical focus.
Applicants will be required to already have a masters degree, or currently be pursuing one if they are applying for the technical doctorate.
The Corps wants officers to get technical degrees in operations research, modeling virtual environments and simulation (MOVES), information sciences, or computer science, the announcement says. Strategy degrees should be geared toward national security, military history, public policy, political science, government, or some other related field.
Applications are being accepted until the end of August 2017.
A US Marine was killed in a stabbing after a fight broke out at Camp Pendleton’s School of Infantry (SOI), according to a San Diego Union-Tribune report published Jan. 16.
One Marine was reportedly in custody. The Naval Criminal Investigative Service (NCIS) is investigating the incident.
First responders were notified at around 7:45 a.m. of an injured person, according to the Union-Tribune.
Located in San Diego County, Camp Pendleton is the primary training center for Marines on the West Coast. After graduating from boot camp, all Marines, regardless of occupational specialty, are sent to the SOI for further combat training before being attached to their units.
The U.S. Marine Corps is rooted in tradition, discipline, and legacy — both on and off the battlefield. For their 244th birthday, we put together a short but noble list of badass Devil Dogs that you may not have heard of before!
From Marine Raiders in the Pacific to the Office of Strategic Services (OSS) officers in North Africa to a World Series champion and a Hollywood heartthrob — this list reminds us that Marines are some of the best the United States has to offer.
1. William A. Eddy
William A. Eddy was an enigmatic figure. He was well-traveled, well-spoken, and had knowledge that many Americans during World War II lacked: an immersion in Islamic culture. Eddy was the son of missionaries and spent his childhood in Sidon, Syria (now Lebanon). He later immigrated to the United States and received an education from Princeton University.
At Princeton, Eddy studied 18th-century literature and Islamic customs, and he developed a fascination with “Gulliver’s Travels” from author Jonathan Swift. During World War I, he exchanged academia for bravery when he was awarded the Navy Cross, the Distinguished Service Cross, two Silver Stars, two Purple Hearts, and the French Fourragère as an intelligence officer. The Battle of Belleau Wood left him severely wounded when an explosive shell peppered his hip, an injury that plagued him for life.
Following the war, Eddy took a job teaching English at American University in Cairo, Egypt, and taught basketball and tennis to students after hours. He wrote the first basketball rulebook in Arabic. In 1941, after professors resigned in protest because of his school curriculum, Eddy said, “College presidency is a job with which I am definitely out of love. I want to be a Marine.” A year later he was commissioned as a major in the Marine Corps, and William Donovan — the founder of the OSS — gave him a cover job as a naval attachè. This cover provided him the access needed to lead all Allied Intelligence across North Africa.
In 1944, he resigned from the Marines to pursue a career that would enhance his love for research, writing, and building relationships. President Franklin Roosevelt asked him to become minister plenipotentiary to Saudi Arabia. Since he spent much of his childhood in the Middle East, Eddy was proficient in the Arabic, French, and German languages. All three are spoken in North Africa, which was an asset in his diplomatic career. He once personally acted as a translator between Roosevelt and King Ibn Saud of Saudi Arabia on the deck of a naval destroyer in the Suez Canal. At the time, he was the only person who could speak both English and Arabic.
A year later, he served in Yemen to develop a U.S. treaty despite not being allies. From 1946 to 1947, he served as special assistant to the secretary of state and was in charge of research and intelligence. When Eddy wasn’t pioneering rapports with Middle Eastern leaders, he and his wife, Mary, enjoyed birdwatching, skiing in Switzerland, and aimlessly traveling the deserts of Lebanon and Beirut. In 1962, he died from a sudden illness at 66 years old. Eddy left behind a legacy as an Arabian Knight who secured the U.S.-Saudi alliance, as well as a war hero, intelligence officer, teacher, and diplomat.
2. Evans Carlson “Carlson’s Raiders”
Like many Marines, Evans Carlson gained his education and life experience through intense combat. Military historian John Wukovitz referred to Carlson as “an intellectual who loved combat; a high school dropout who quoted Emerson; a thin, almost fragile-looking man who relished fifty-mile hikes; an officer in a military organization that touted equality among officers and enlisted; a kindly individual with the capacity to kill; the product of small New England towns who sought adventure in vast reaches of the world; a man who believed in decency and love and fairness, but whose actions generated bitterness hatred and empathy.”
After running away from his Vermont home at age 14 and lying about his age at 16, Carlson enlisted in the Army in 1910 and matured as a man in a time of war. His duration in the Army was short, though worth noting because his service in the Pacific resulted in many promotions. He advanced to sergeant major and later was commissioned as a 2nd lieutenant, deploying to Europe just in time for the armistice agreement to be approved. In 1919, he left the Army and mingled around the civilian world before enlisting in the Marine Corps with a reduced rank.
Evans Carlson in uniform with a chest full of medals from his time in 2nd Raider Battalion.
As an officer, Carlson proved himself in Nicaragua with a team of just 12 Marines. They repelled 100 bandits, and he was awarded his first Navy Cross. Later, between 1937 and 1939, he was a witness to the developments of the Chinese army. While living among their forces, Carlson traveled thousands of miles on horseback through difficult terrain. He jotted down his findings and studied the tactics of Japanese foot soldiers. As an author of two books — “The Chinese Army” and “Twin Stars of China” — Carlson was an advocate for the Chinese, who he thought could be an ally in the Pacific against the aggressive Japanese military.
In 1941, he led the 2nd Marine Raider Battalion and called his unit the “Kung-ho (Work Together)” or “Gung-ho Battalion.” Others called them Carlson’s Raiders. He valued each man by their merit, not by their title. Carlson utilized his past experiences from his three trips to China to build rapport with allied-native forces and hit the Japanese in shock-and-awe violence.
While aboard two submarines — the USS Nautilus SS-168 and the USS Argonaut SM-1 — traveling from Pearl Harbor, the Marine Raiders were tasked with a secret mission to attack the island of Butaritari (sometimes referred to as Makin Island). Although they trained for this mission using light rubber boats, Murphy’s Law always has a say in real-world operations. At 3:30 AM, the Raiders launched 20 boats from the submarine — 11 men each — into the heavy surf and rain. Some of the equipment, such as mortars and mission essential supplies, were lost at sea because they weren’t tied down.
Adding to the confusion, one soldier accidentally discharged his weapon, which erased the element of surprise. Carlson phoned the submarine on the radio with a SITREP and said, “Everything lousy.” Alongside legendary Chinese Marine Sergeant Victor Maghakian — who served in the famed Shanghai Municipal Police — the Raiders successfully deceived the Japanese into believing this amphibious landing was the main assault, thus drawing attention from Guadalcanal. For his decisive leadership, Carlson received a Gold Star for his second Navy Cross.
In November, the Carlson’s Raiders reached Guadalcanal and hiked 18 miles through dense jungle foliage. This hike was later called Carlson’s patrol or the long patrol and has since reached legendary battlefield status. Led by native scouts — and in just 29 days — 488 Japanese soldiers were killed, 16 Americans killed in action (KIA), and 18 Americans wounded. The success of the operation was largely due to the guerilla warfare tactics the unit employed, the understanding of the Japanese fight-to-the-death mantra, and the effectiveness of small units and their capabilities.
3. Merritt A. Edson
Merritt A. Edson’s path was similar to Evans Carlson’s. Both were commanders of a Marine Raider Battalion — Edson leading the 1st and Carlson leading the 2nd. Prior to World War II, Edson pursued an aviation career but made the transition as a grunt from 1928 to 1929. During that span, he fought 12 separate ground engagements against Nicaraguan bandits, which earned him his first Navy Cross. This is where his nickname, “Red Mike,” was born because he wore a long, red beard during the fighting. This is also where his platoon of specially trained Marines honed a capability they would use during World War II.
Edson is most notably remembered for his heroism on what was later described as “Edson’s Ridge” (Lunga Ridge) near the captured Japanese airfield later renamed Henderson Field on Guadalcanal on Sept. 13-14, 1942. Edson’s Raider Battalion, enforced with two companies from the 1st Parachute Regiment, were hunkered down to rest on a warm August evening. A numerically superior force of 2,500 heavily armed and determined Japanese launched an all-out ambush that initially overwhelmed the estimated 800 Marines. Edson called for his men to push back to avoid being overrun.
Merritt “Red Mike” Edson, Medal of Honor Recipient and Marine Raider during World War II.
Edson told his Marines to prepare for their final stand as they began mowing down the waves of charging Japanese soldiers. They effectively repelled the attack, and Edson’s fierce leadership was awarded with the Medal of Honor. After World War II, Edson was promoted to major general before retiring from the military in 1947. However, his service didn’t end there — he became the first commissioner of the Vermont State Police, the state in which he grew up. The state police uniform was modeled after the Marines, and the troopers were structured in a paramilitary-type ranking system. When Bennington College student Paula Weldon disappeared in 1946, Edson helped establish the Department of Public Safety. The case has remained unsolved, but it was a driving force in creating an organization to effectively solve crimes in a unified manner rather than allocating help from outside state and federal resources.
Edson’s practices and innovation in the police force encouraged other departments and agencies to follow suit. In 1948, the first state police radio system allowed stations and patrol cars to communicate with each other. And in 1949, an Identification and Records Division was established, which ultimately changed the future of policing. After four years of dedicated service, Edson retired in 1951. Four years later, he committed suicide by carbonmonoxide poisoning in the garage of his home in Washington, D.C. At the time, he was working for the National Rifle Association.
4. Sterling Hayden
To his fellow Marines, Hollywood heartthrob Sterling Hayden was known by his alias, John Hamilton. At age 22, Hayden had already secured a master’s certificate in sailing, and his passion was at sea. He used his acting career to fund his adventurous sea voyages. “I just laughed it off at the time,” he said in an interview in 1972. “But a year or so later, when I had finally managed to buy my own ship only to see her irreparably damaged on her first voyage, a few months in Hollywood seemed like a quick and easy way to get enough dough and buy another one.”
Hayden thought his acting chops were lacking and was waiting for someone to tap him on the shoulder and ask what he was doing there. Others, especially women, saw a 6-foot-4, blonde, and handsome character actor with a soft smile who was easy on the eyes. He married British actress Madeleine Carroll, who was known for her roles in Alfred Hitchcock’s “39 Steps” and “Secret Agent.” The pair were a fair match as both had resentments about Hollywood, but for Hayden, who grew up idolizing World War I ace fighter pilot Eddie Rickenbacker, more adventures were waiting. He was commissioned as a 2nd lieutenant in the Marines during World War II as a secret intelligence and paramilitary organization was being created for which they were in search of Marines with advanced skills.
Sterling Hayden at the helm of the Wanderer.
(Photo courtesy of Sausalito Historical Society.)
In order to operate undercover at the OSS, he adopted an alias, which was common practice for OSS officers. As John Hamiliton, Hayden was sent to commando school in Britain to learn parachute skills and tradecraft from the Special Operations Executive (SOE). He then assumed his pastime as a sailor, except this time he was running guns through German-patrolled waters to Josip Broz Tito’s partisan forces in Yugoslavia. From Christmas Eve 1943 to Jan. 2, 1944, Captain Hamilton operated clandestine missions through hazardous waters and scouted enemy positions for reconnaissance. He was awarded the Silver Star for his actions.
When Hamilton first met OSS officers, he said it was “the first time since joining the OSS that I was associated with men who were actually doing a job.” Hamilton later sailed another mission carrying food and nourishment to the Yugoslav people, who were cut off from outside assistance. Captaining a 50-foot Italian fishing vessel, their crew crept through the Adriatic Sea off the Albanian coast completely unarmed. Between February and April, they made 10 trips. Hayden later commented: “By plunging through the Allied minefield late of an afternoon a schooner always had a fighting chance of reaching Vis at dawn—barely in time to be backed into a precipitous cove where she could be hastily camouflaged with pine boughs festooned in her rigging, unloaded the following night, the camouflage repeated, and then driven toward Italy as soon as the weather served.”
In the summer, he was tasked with transporting 40 tons of explosives near the shores of Croatia, but the mission was passed to the SOE at the last minute. When the war ended, Hayden returned to his old habits, sailing the world with legendary seafarer Spike Africa and his children, writing of his adventures in his popular autobiography “Wanderer” and his novel “Voyage,” and acting in popular movies. He appeared in “The Godfather” as the chief of police and in Stanley Kubrick’s “The Killing” and “Dr. Strangelove.” He died in 1986 at age 70.
5. Hank Bauer
Hank Bauer was a New York Yankees all-star who played on the same team as baseball icons Joe DiMaggio, Yogi Berra, and Mickey Mantle. One sportswriter described him as having “a face like a clenched fist.” Bauer holds the record for the longest hitting streak in World Series history, with at least one hit in 17 consecutive games. He is also a World Series Champion, both as a player and as a manager for the Baltimore Orioles.
Despite all his success as an athlete, Bauer said his brother, Herman, who was killed in action in France in 1944 during World War II, was the family’s best player. Like his brother, Bauer served during the war, but with the elite unit known as the Marine Raiders. While serving with the 4th Raider Battalion in the Pacific, Bauer’s immune system had a problem with malaria — or that’s what outsiders would tell you, since he contracted and fought the disease 23 times. This was largely due to his stubbornness as he refused to take atabrine pills to prevent it.
Bauer saw action on the islands of New Georgia, located north of Guadalcanal, and he recalled it as “indescribable — the worst [place he had] ever seen.” As the Marines island-hopped across the Pacific, Bauer was wounded by shrapnel on two separate occasions. During the Battle of Okinawa, Bauer was the platoon leader for 64 Marines. Only six of them survived the hellacious fighting. In 32 months of combat, he was awarded two Bronze Stars and two Purple Hearts.
Steve Fredericks, one of the Marines in Bauer’s platoon, said, “On Guadalcanal when things quieted down, he had a baseball glove and I’d go out and have a catch with him. You could tell he played, but it didn’t enter my mind [that he could be professional]. When I got back to the states I heard him on the radio and watched him on TV. But it didn’t surprise me; he was built. He was all muscle. He was a strong man.”
Remembering D-Day with World War II Vets in Normandy
Researchers have identified a compound that blocks the spread of pancreatic and other cancers in various animal models. When cancer spreads from one part of the body to another in a process called metastasis, it can eventually grow beyond the reach of effective therapies. Now, there is a new plan of attack against this deadly process, thanks to scientists at the National Institutes of Health, Northwestern University and their collaborative research partners.
The team collaborated to identify a compound, which they named metarrestin, that stopped tumor metastasis in multiple animal models. Mice treated with metarrestin also had fewer tumors and lived longer than mice that did not receive treatment. These results were published May 16, 2018, in Science Translational Medicine.
In patients, metarrestin potentially could be effective as a therapy after cancer surgery. Because advanced cancers are difficult to completely remove with surgery, doctors typically give chemotherapy to try to kill undetected cancer cells left behind and prevent the cancer from coming back. Metarrestin could be added to such standard drug therapy.
Metarrestin breaks down an incompletely understood component of cancer cells called the perinucleolar compartment (PNC). PNCs are found only in cancer cells, and in a higher number of cells in advanced cancer, when it has spread to other sites in the body.
Co-author Sui Huang, M.D., Ph.D., and her colleagues at Northwestern University Feinberg School of Medicine, Chicago, showed early on that the more cancer cells with PNCs in a tumor, the more likely it would spread. Her findings suggested that reducing PNCs might translate to less cancer progression and possibly better outcomes in patients.
To test these ideas, Huang approached Marugan to tap into NCATS’ expertise in screening, chemistry, compound development and testing to evaluate more than 140,000 compounds for their potential effectiveness in eliminating PNCs in cells in advanced cancer.
While nearly 100 compounds initially showed some activity, the investigators identified one compound that could effectively break down PNCs in advanced prostate cancer cells. With the help of researchers at the University of Kansas, Lawrence, they modified the compound to make it work better as a potential drug and evaluated the effects of the molecule in different assays, or tests, in the laboratory. They found that metarrestin could block the way prostate and pancreatic cancer cells spread.
In collaboration with co-author Udo Rudloff, M.D., Ph.D., from NIH’s National Cancer Institute’s (NCI) Center for Cancer Research, the group evaluated the effects — including toxicity — of metarrestin in pancreatic cancer mouse models. The investigators found that it prevented the further spread of pancreatic cancer by disrupting the protein-making machinery of cancer cells, and mice treated with metarrestin lived longer than mice without treatment.
“Cancer cells are rapidly dividing and need to make more proteins than healthy cells to help carry out various activities, including the ability to spread,” Rudloff said. “Interfering with the system stalls cancer cell metastasis.”
Rudloff and his NCI group currently are working with scientists at the NCATS-led Bridging Interventional Development Gaps program to collect the pre-clinical data on metarrestin needed to further its development as a candidate drug. The scientists plan to file an Investigational New Drug (IND) application in the fall with the U.S. Food and Drug Administration (FDA). FDA IND approval is necessary before a candidate drug can be tested in patients.
The research was funded by NCATS and NCI through their intramural programs, and in addition, the National Human Genome Research Institute grant U54HG005031, the National Institute of General Medical Sciences grants R01GM078555 and R01GM115710, NCI grant 2 P30 CA060553-19, the V Foundation, a donation from the Baskes family to the Robert H. Lurie Comprehensive Cancer Center, donations from ‘Running for Rachel’ and the Pomerenk family via the Rachel Guss and Bob Pomerenk Pancreas Cancer Research Fellowship to NCI, the Robert H. Lurie Comprehensive Cancer Center – Translational Bridge Program Fellowship in Lymphoma Research and the Molecular Libraries Initiative funding to the University of Kansas Specialized Chemistry Center.
About the National Center for Advancing Translational Sciences (NCATS): NCATS conducts and supports research on the science and operation of translation — the process by which interventions to improve health are developed and implemented — to allow more treatments to get to more patients more quickly. For more information about how NCATS is improving health through smarter science, visit https://ncats.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
Tensions escalated along the Korean Peninsula early in December as U.S. stealth fighters prepared for a joint military drill with South Korea, with North Korea accusing the U.S. of having “nuclear war mania.”
North Korea made several statements about actions taken by the U.S. over the weekend.
North Korea’s Foreign Ministry said in a statement, read on state TV, that President Donald Trump and his administration were “begging for nuclear war” by engaging in what the statement referred to as an “extremely dangerous nuclear gamble,” CNN reported.
The statement also said that if the Korean Peninsula and the world were to be pushed to nuclear war, the U.S. would be “fully responsible” because of its “reckless nuclear war mania.”
Then, on Dec. 3rd, commentary run by state TV called the U.S.-South Korea joint air exercises a “dangerous provocation,” pushing the region “to the brink of a nuclear war,” according to CNN. North Korean media regularly threatens the U.S. and its allies and blames the U.S. for tensions on the peninsula.
The U.S. and its ally South Korea began their largest cooperative air exercise in history, dubbed Vigilant Ace, Dec. 4.
The U.S. Air Force said in a statement that F-22 and F-35 stealth jets had moved into South Korea over the weekend in preparation for the joint drill. About 230 aircraft and 12,000 U.S. personnel are expected to participate in the week-long exercise, which will include more stealth jets than ever before.
According to the U.S. Air Force, the move is designed to boost the “combat effectiveness” of the alliance.
The White House national security adviser, H.R. McMaster, said Dec. 2 the chances for nuclear war on the peninsula were growing, CNN reported.
“I think it’s increasing every day, which means that we are in a race, really, we are in a race to be able to solve this problem,” McMaster said in a conference in California, when asked whether North Korea’s intercontinental ballistic missile launch last week had increased the chance of war.
McMaster also said North Korea represented the “the greatest immediate threat to the United States.”
As Black History Month draws to a close, so does the mystery of U.S. Army Air Forces Capt. Lawrence E. Dickson, a Tuskegee Airman declared missing in action after his plane crashed in Europe in December 1944.
Dickson’s remains were identified in November 2018 using the latest DNA tests, making him the first to be identified out of more than two-dozen Tuskegee Airmen declared MIA during World War II.
Brig. Gen. Twanda E. Young, deputy commanding general of the U.S. Army’s Human Resources Command, recognized Dickson’s service Feb. 24, 2019, during a ceremony at the Fountain Baptist Church here.
Marla L. Andrews (center), daughter of U.S. Army Air Forces Capt. Lawrence E. Dickson, receives her father’s medals from Brig. Gen. Twanda E. Young, deputy commanding general of the U.S. Army’s Human Resources Command.
(Photo by Staff Sgt. Shawn Morris)
“I stand before you deeply honored and humbled to represent the United States Army, as well as all African-American service members across all military services and those who have long served before me, to commemorate and acknowledge the honorable service rendered by Capt. Lawrence E. Dickson in service to a grateful nation,” Young said.
“Capt. Lawrence Dickson shaped my future, which affords me the distinct honor of being one of a few African-American female general officers serving in the United States Army,” she added.
Marla L. Andrews (left), daughter of U.S. Army Air Forces Capt. Lawrence E. Dickson, delivers remarks during a Feb. 24, 2019 ceremony held at Fountain Baptist Church in Summit, N.J., to recognize her father’s military service.
(Photo by Staff Sgt. Shawn Morris)
During the ceremony, Young presented Dickson’s Distinguished Flying Cross, Purple Heart, Air Medal, American Campaign Medal, Europe-African-Middle Eastern Campaign Medal, World War II Victory Medal, and Honorable Service Lapel Button to Marla L. Andrews, Dickson’s daughter.
“I feel happy that we’re able to do this this morning here with you, because the things that are most important to us are better shared,” said Andrews, who as two years old when her father died.
“These medals represent a part of our history, along with the Tuskegee Airmen’s perseverance and determination, coupled with the courage and legacy of Capt. Lawrence Dickson,” Young said. “The country called, and Capt. Dickson answered.”
Brig. Gen. Twanda E. Young, deputy commanding general of the U.S. Army’s Human Resources Command, delivers remarks during a Feb. 24, 2019 ceremony held at Fountain Baptist Church in Summit, N.J., to recognize U.S. Army Air Forces Capt. Lawrence E. Dickson’s military service.
(Photo by Staff Sgt. Shawn Morris)
In December 1944, Dickson was a pilot with the 100th Fighter Squadron, 332nd Fighter Group, in the European Theater, according to a Defense POW/MIA Accounting Agency news release. On Dec. 23, 1944, Dickson departed Ramitelli Air Base, Italy, on an aerial reconnaissance mission toward Praha, Czechoslovakia.
During his return, Dickson’s P-51D aircraft suffered engine failure and was seen to crash along the borders of Italy and Austria. Dickson’s remains were not recovered and he was subsequently declared missing in action.
Marla L. Andrews (right), daughter of U.S. Army Air Forces Capt. Lawrence E. Dickson, receives her father’s medals from Brig. Gen. Twanda E. Young, deputy commanding general of the U.S. Army’s Human Resources Command.
(Photo by Staff Sgt. Shawn Morris)
Seventy-three years later, an excavation of a crash site was conducted and recovered remains were sent to the DPAA laboratory at Offutt Air Force Base, Nebraska. To identify Dickson’s remains, scientists from DPAA and the Armed Forces Medical Examiner System used DNA analysis as well as anthropological analysis, and circumstantial and material evidence.
“The men and women who have given their lives in service to this nation are indisputably heroes,” Young said.
Dickson is scheduled to be buried March 22, 2019, in Arlington National Cemetery, near Washington, D.C.
Russian President Vladimir Putin’s annual call-in question show on June 7, 2018, contained broad talk of improving Russia’s economy and of the coming Russia-hosted World Cup — but also some ominous warnings about World War III.
Putin frequently frames his country as resisting Western aggression designed to hold back Russia, often citing Western sanctions.
The US and other Western countries sanctioned the Russian economy in 2014 over its illegal annexation of Crimea, a Ukrainian peninsula on the Black Sea.
Asked about those sanctions on June 7, 2018, Putin said they were “because Russia is seen as a threat, because Russia is seen as becoming a competitor.”
“It is clear to us that we have to defend our interests and to do so consistently, not boorishly or rudely, in both the sphere of the economy and of defense,” Putin said. “The pressure will end when our partners will be persuaded that the methods they are using are ineffective, counterproductive, and harmful to all.”
Asked whether “nonstop” sanctions could lead to World War III, Putin pulled an Albert Einstein quote to deliver a dark warning.
“‘I know not with what weapons World War III will be fought, but World War IV will be fought with sticks and stones,'” he said, NBC News reports.
“A third world war could be the end of civilization,” Putin went on, saying the high stakes “should restrain us from taking extreme steps on the international arena that are highly dangerous for modern civilization.”
Perhaps more than any other country, Russia has the nuclear capability to end the world. With about 7,000 nuclear weapons making up the world’s most diverse and destructive nuclear arsenal, Putin could unilaterally decide to embark on a civilization-ending war.
Additionally, by annexing Crimea, Putin changed land borders in Europe by force. In peacetime, that most recently happened in the run-up to World War II.
But Putin also gave a nod to the force keeping his nuclear and military ambitions in check: mutually assured destruction. Basically, if Putin decides to let nukes fly, the US is sure to respond in kind, destroying Russia as well.
“The threat of mutual destruction has always restrained participants of the international arena, prevented leading military powers from making hasty moves, and compelled participants to respect each other,” he said.
Putin then said the US withdrawing from a ballistic-missile defense treaty would make Russia “respond.”
So far, Putin’s response has included building what experts call a nuclear “doomsday device,” an underwater torpedo that could render large tranches of the world uninhabitable for decades.
This article originally appeared on Business Insider. Follow @BusinessInsider on Twitter.
The Air Force is finishing engineering details on an aggressive plan to prototype, test, and deploy hypersonic weapons on an expedited schedule — to speed up an ability to launch high-impact, high-speed attacks at five times the speed of sound.
Recent thinking from senior Air Force weapons developers had held that US hypersonic weapons might first be deployable by the early 2020s. Hypersonic drones for attack or ISR missions, by extension, were thought to be on track to emerge in the 2030s and 2040s, senior service officials have told Warrior Maven.
Now, an aggressive new Air Force hypersonic weapons prototyping and demonstration effort is expected to change this time frame in a substantial way.
“I am working with the team on acceleration and I am very confident that a significant acceleration is possible,” said Dr. Will Roper, Assistant Secretary of the Air Force for Acquisition, Technology and Logistics.”
The effort involves two separate trajectories, including the Air-Launched Rapid Response Weapon and a Hypersonic Conventional Strike Weapon.
“The Air Force is using prototyping to explore the art-of-the-possible and to advance these technologies to a capability as quickly as possible. We continue to partner with DARPA on two science and technology flight demonstration programs: Hypersonic Air-breathing Weapon Concept and Tactical Boost Glide,” Maj. Emily Grabowski, Air Force spokeswoman, told Warrior Maven.
A “boost glide” hypersonic weapon is one that flies on an upward trajectory up into the earth’s atmosphere before using the speed of its descent to hit and destroy targets, senior officials said.
The Hypersonic Conventional Strike Weapon effort involves using mature technologies which have not yet been integrated for air-launched delivery, Grabowski added.
“The ARRW effort will “push the art-of-the-possible” by leveraging the technical base established by the Air Force/DARPA partnership,” she said. “The two systems have different flight profiles, payload sizes, and provide complementary offensive capabilities.”
The Air Force recently took a major step forward in the process by awarding an HCSW prototyping deal to Lockheed Martin.
As the most senior Air Force acquisition leader who works closely with the services’ Chief of Staff, Roper was clear not to pinpoint an as-of-yet undetermined timeline. He did, however, praise the hypersonic weapons development team and say the particulars of the acceleration plan would emerge soon. Roper talked about speeding up hypersonic weapons within the larger context of ongoing Air Force efforts to streamline and expedite weapons acquisition overall.
Roper explained the rationale for not waiting many more years for a “100-percent” solution if a highly impactful “90-percent” solution can be available much sooner. Often referred to as “agile acquisition” by Air Force senior leaders, to include service Secretary Heather Wilson, fast-tracked procurement efforts seek quicker turn around of new software enhancements, innovations, and promising combat technologies likely to have a substantial near-term impact. While multi-year developmental programs are by no means disappearing, the idea is to circumvent some of the more bureaucratic and cumbersome elements of the acquisition process.
The Air Force, and Pentagon, need hypersonic weapons very quickly, officials explain, and there is broad consensus that the need for hypersonic weapons is, at the moment, taking on a new urgency.
A weapon traveling at hypersonic speeds, naturally, would better enable offensive missile strikes to destroy targets such and enemy ships, buildings, air defenses and even drones and fixed-wing or rotary aircraft depending upon the guidance technology available.
A key component of this is the fact that weapons traveling at hypersonic speeds would present serious complications for targets hoping to defend against them – they would have only seconds with which to respond or defend against an approaching or incoming attack.
Along these lines, the advent of hypersonic weapons is a key reason why some are questioning the future survivability of large platforms such as aircraft carriers. How are ship-based sensors, radar and layered defenses expected to succeed in detecting tracking and intercepting or destroying an approaching hypersonic weapon traveling at five-times the speed of sound.
Hypersonic weapons will quite likely be engineered as “kinetic energy” strike weapons, meaning they will not use explosives but rather rely upon sheer speed and the force of impact to destroy targets.
A super high-speed drone or ISR platform would better enable air vehicles to rapidly enter and exit enemy territory and send back relevant imagery without being detected by enemy radar or shot down.
Although potential defensive uses for hypersonic weapons, interceptors or vehicles are by no means beyond the realm of consideration, the principle effort at the moment is to engineer offensive weapons able to quickly destroy enemy targets at great distances.
Some hypersonic vehicles could be developed with what senior Air Force leaders called “boost glide” technology, meaning they fire up into the sky above the earth’s atmosphere and then utilize the speed of descent to strike targets as a re-entry vehicle.
The speed of sound can vary, depending upon the altitude; at the ground level it is roughly 1,100 feet per second. Accordingly, if a weapon is engineered with 2,000 seconds worth of fuel – it can travel up to 2,000 miles to a target, senior weapons developers have told Warrior.
While Roper did not address any specific threats, he did indicate that the acceleration is taking place within a high-threat global environment. Both Russia and China have been visibly conducting hypersonic weapons tests, leading some to raise the question as to whether the US could be behind key rivals in this area.
“We are not the only ones interested in hypersonics,” Roper told reporters.
A report cited in The National Interest cites a report from The Diplomat outlining Chinese DF-17 hypersonic missile tests in November 2017.
During the tests – “a hypersonic glide vehicle detached from the missile during the reentry phase and flew approximately 1,400 kilometers to a target,” The Diplomat report states.
Also, Pentagon is fast-tracking sensor and command and control technology development to improve defenses against fast-emerging energy hypersonic weapons threats from major rivals, US Missile Defense Agency officials said in early 2018.
This article originally appeared on Warrior Maven. Follow @warriormaven1 on Twitter.
Kazakhstan has long been an important military partner for the Russian government and remains the launching pad for Moscow’s space program.
This year, more than 3,000 military personnel representing 19 countries descended on the Central Asian nation to participate in a series of war games dubbed “The International Army Games.” Russia and Kazakhstan (a former Soviet Republic) will each hold events for the games, which runs through August 13th and kicked off with the Tank Biathlon.
This year’s list of competitions includes 23 different events, including those listed below.
Most competitions are for the Army, including 17 of the 23 events. Three are for air forces and two are for naval forces. The naval exercises will be held in Russia since Kazakhstan is landlocked.
The Russian military invited 47 countries to the games, including the U.S. and its NATO allies. Greece, who sent a team to the sniper event, is the only NATO partner that accepted Russia’s invite.
The games themselves date back to the days of the USSR, when Soviet and Warsaw Pact troops would compete to hone their martial skills during peacetime.
“For many soldiers, specialists in particular, peacetime can present what we call unrealized professional syndrome,” Igor Sutyagin, a Russian military expert, told Newsweek. “They train all their life for something and they never test their skills. These competitions between crews give them a chance to feel they are the best at what they do and in particular the focus is important in support and combat support staff, such as cooks.”
The 121 teams include armies that might not be best of friends with the U.S., including the Chinese People’s Liberation Army and the Iranian Islamic Revolutionary Guard Corps. Iran also sent its Basij soldiers and some police officers to compete.
“We are ready to emulate various tactical and technical things from our partners from Russia and other countries, and get acquainted with the arms they use,” Iranian Col. Mehdi Ahmadi Afshar told Sputnik News, a Russian government-controlled news agency. “We are looking forward to honest competition and fruitful cooperation with our colleagues here.”