Recently, the Afghan Air Force grabbed headlines by dropping its first laser-guided bomb. From here, that might not seem so impressive — the U.S. dropped laser-guided Paveways in Vietnam as early as 1968. But, considering the fact that their military force was decimated by a civil war that began after the Soviets left in 1989, Afghanistan’s military modernization is quite the shock.
Today, as World Air Forces 2018 notes, the Afghan Air Force has 12 A-29 Super Tucanos (with six more on order) as well as 28 MD530Fs (with 154 on order) and ten UH-1H Iroquois utility helicopters. The Afghan Air Force is also acquiring almost 160 UH-60A Blackhawk helicopters, four of which have already been delivered. These aircraft are set to replace a fleet of Russian-designed Mi-8/Mi-17 Hip transport helicopters and Mi-25 Hind attack helicopters.
Afghan Air Force MD-530F Cayuse Warrior helicopter fires its two FN M3P .50 cal machine guns
(U.S. Air Force Photo by Staff Sgt. Perry Aston)
The Super Tucano is currently a finalist in the OA-X competition (alongside the Beechcraft AT-6B). The UH-60A Blackhawk helicopters are second-hand, but will be upgraded with a newer engine and rocket pods before delivery. Afghanistan is also going to acquire Cessna 208 Caravan light transport aircraft armed with AGM-114 Hellfire missiles.
But did you know that, thirty years ago, the Afghan Air Force packed a lot of punch? An inventory of older equipment shows a lengthy list of Soviet designs were once in service, ranging from the Il-28 Beagle and MiG-17 Fresco to the MiG-23 Flogger. But 12 years of civil war wore that force down substantially. By the time Operation Enduring Freedom began, less than 20 planes were flyable. After Operation Enduring Freedom, there simply wasn’t an Afghan Air Force.
One of what will be up to 160 UH-60A Blackhawks for the Afghan Air Force.
(U.S. Air Force photo by Staff Sgt. Jared J. Duhon)
We’ve got a long way to go before the Taliban, al-Qaeda, and ISIS are defeated in Afghanistan, but the new Afghan Air Force should help speed that process along.
An F-16 pilot flying over ISIS-held territory in 2015 suffered a malfunction of his fuel system and would have been forced to bail out if it weren’t for a KC-135 Stratotanker crew that offered to escort the jet home, the Air Force said in a press release.
“We were in the area of responsibility and were already mated with some A-10 Thunderbolt IIs that were tasked with observing and providing close-air-support for our allies on the ground,” said Capt. Nathanial Beer, 384th Air Refueling Squadron pilot. “The lead F-16 came up first and then had a pressure disconnect after about 500 pounds of fuel. We were expecting to offload about 2,500 pounds.”
After the pilot completed his checklist, it became apparent that 80 percent of his fuel supply was trapped in the tanks and couldn’t get to the engine. The pilots would have to bail out over ISIS territory or try to make it back to allied airspace.
500 pounds of fuel is very little in an F-16, so the KC-135 flew home with the fighter and topped off its gas every 15 minutes.
“The first thought I had from reading the note from the deployed location was extreme pride for the crew in how they handled the emergency,” said Lt. Col. Eric Hallberg, 384th Air Refueling Squadron commander.
“Knowing the risks to their own safety, they put the life of the F-16 pilot first and made what could’ve been an international tragedy, a feel-good news story. I’m sure they think it was not a big deal, however, that’s because they never want the glory or fame.”
The KC-135 crew returned to their planned operation once the F-16 was safely home and were able to complete all of their scheduled missions despite the detour.
Georgia Army National Guard Spc. Jason A. Warren, an aircraft powertrain repairer with the Marietta, Georgia-based Company D, 1st Battalion, 171st Aviation Regiment, and his wife Cortney garnered national media attention on Feb. 9, 2018, when their son, Lucas, was named the 2018 Gerber Spokesbaby.
The Warrens were amazed when they received the news of Lucas’ win.
“Absolute shock,” said Jason. “It was hard to believe he won out of 140,000 entries.”
Lucas, diagnosed with Down syndrome, is the eighth Gerber baby since the contest began in 2010. Inspired by the original Gerber baby sketch of Ann Turner Cook, families began sharing their baby photos with Gerber. In response, Gerber launched its first official photo search competition in 2010.
Georgia Guardsman Spc. Jason Warren smiles for a picture with his wife Cortney and son Lucas. (Courtesy photo via U.S. Army)
“We hope this opportunity sheds light on the special needs community and educates people that with acceptance and support, individuals with special needs have potential to change the world,” said Cortney. “Just like our Lucas.”
The Warrens hope other families with special needs children can look to Lucas as a source of inspiration.
“We hope this will help people kick-start their own lives and give them more confidence,” said Jason. “They might think if Lucas can do this, what can I do in my life?”
The winning photo shows Lucas, sitting in an overstuffed chair, grinning from ear to ear wearing a black and pink polka-dot bow tie.
“He is very outgoing and never meets a stranger,” said Cortney. “He loves to play, loves to laugh, and to make other people laugh.”
“He is just the absolute cutest thing ever,” said Staff Sgt. Misty D. Crapps, supply sergeant with Company D, 171st Aviation Regiment. “He always smiles at everybody he sees.”
Georgia Guardsman Spc. Jason Warren smiles for a photo with his wife Cortney and son Lucas. (Courtesy photo via U.S. Army)
Jason looks forward to continued service in the Georgia Army National Guard. He feels a sense of pride and family being part of the organization.
“I absolutely love the Guard: the ability to help my community and serve my country,” said Jason. “The benefits of service are always great to have, and it allows me to serve my country the way I want to.”
The fellowship of his teammates in his aviation unit also reinforces the feeling of family.
“The Guard has been with me with everything I’ve ever done,” said Jason. “Through my grandmother’s passing, when I had shoulder surgery, they’ve helped Cortney and me a lot, and they are a second family to us.”
Lucas Warren, the 2018 Gerber Spokesbaby. (Courtesy photo via U.S. Army)
The aviators and Guardsmen in Jason’s unit share his feeling for service in the Guard and look forward to his continued service.
“He always volunteers to do the little things which are not part of his job description to make the unit better,” said 1st Sgt William W. Adcock of Company D, 171st Aviation Regiment. “Specialist Warren is a fantastic Guardsman. He does what we all do: dedicates his time and personal energy to serve the people of this state and the United States.”
Jason plans to re-enlist in March 2018 for another six years and hope Lucas sees him and understands the importance of service.
“I hope one day Lucas will see I was in the military and has a sense of pride,” said Jason.
Fortnite, the wildly popular (and highly addictive) video game of 2018, is back — with a new line of themed toys just in time for summer 2019. Hasbro revealed that it’s teaming up with the gaming brand on eight different Nerf dart blasters and super soakers that will be released on March 22, 2019.
Announced at the New York Toy Fair 2019, the Fortnite x Nerf line is inspired by the same weapons used by the characters in Fortnite, imitating the same style and color scheme. There are five types of dart blasters and three types of super soakers that kids and parents can choose from.
In terms of dart blasters, there are some smaller versions that shoot micro-darts and another one that’s shaped like the Loot Llama. However, the real highlight is likely the AR-L Elite Dart Blaster. Equipped with a motorized shooting system and a 10-dart clip, it retails for .99, the most expensive of the bunch.
As for the water guns, you can select the standard super soaker, the pump action model, or the colorful rocket launcher. Of the three, the TS-R Super Soaker Water Blaster Pump Action is the largest, holding up to 36 fluid ounces (1 liter) of water.
The most interesting thing about pleading guilty to a capital crime in a military court is the defendant needs to be able to convince the presiding judge that he or she is actually guilty of the crime, and not just taking the deal to avoid the death penalty. Another interesting tidbit is that defense lawyers can only allow the defendant to make such a plea if they truly believe he or she is guilty.
So when Staff Sgt. Alberto Martinez offered to plead guilty to avoid the death penalty for murdering two of his officers in Iraq, you’d think that would be a gift to the prosecution. You’d think that, you really would.
Lt. Allen left behind four children with his wife.
Martinez convinced his lawyers of his guilt and offered to plead guilty to premeditated murder, convince the judge, and avoid the death penalty. He was willing to testify that he threw a claymore mine into the window of a CHU occupied by his commanding officers, Capt. Phillip T. Esposito and First Lt. Louis E. Allen on a U.S. military base near Tikrit, Iraq in 2005.
The claymore exploded and tore the two sleeping officers to shreds, as it was designed to do. It was the first fragging accusation of the Global War on Terror. Witnesses told the 14-member jury that Esposito derided Martinez for his lax operation of the unit’s supply room. Another witness testified that she had delivered the murder weapon to Martinez a month prior. Another witness said Martinez simply watched the explosion happen, unconcerned about a follow-on attack. It was a well-known fact that Martinez and Esposito did not get along.
A temporary memorial for US Army officers Phillip Esposito and Louis Allen erected in Tikrit, Iraq in June 2005 after both officers were killed in an alleged fragging incident at Forward Operating Base Danger on June 7, 2005.
Martinez was arrested and transferred to Fort Bragg for trial. A New York Times investigation revealed that Martinez offered the guilty plea two full years before his trial ever took place – but the offer was rejected by the prosecution, who wanted to send Martinez to death row.
If the defense offered it to the prosecution, it means they truly believed their client was guilty, as per Army regulations. Then Martinez would have to convince the judge of his guilt. The judge could then accept or reject the plea. Martinez never made it to the judge. The Army took it to trial and lost their case against Martinez in just six weeks.
Esposito with his daughter Madeline before deploying in 2005.
The defense argued that all the evidence and witness accounts were purely circumstantial and since no one took receipt of the claymores, which was usual for the Army then, it can’t be proven that Martinez had access to them or even knew the rarely-used mines were available.
Martinez was cleared of the charges, released from prison, and honorably discharged from the Army. He died in January 2017 of unknown causes, and no charges have ever been filed for the deaths of Capt. Esposito and Lt. Allen.
Navy SEAL candidates go through some of the hardest military training known to man before earning their beloved Trident. When young men across the country join the Navy, they head to the sandy beaches of Coronado, California to test themselves and see if they have what it takes to become one of the elite.
Since the BUD/S drop-out rate is so freakin’ high, many are left wondering what it truly takes to survive the rigorous training and successfully graduate the program.
Well, Jason Phalin, a former Navy SEAL who spent 20 years in the elite force, is here to break down a few tips that just might get you through.
During a Hell Week surf drill evolution, a Navy SEAL instructor assists students from Basic Underwater Demolition/SEAL (BUD/S) class 245 with understanding the importance of listening.
(Photo by U.S. Navy Photographer’s Mate 2nd Class Eric S. Logsdon)
1. Be physically fit
BUD/S training is widely known for being one of the most physically demanding training pipelines in the world. If you fail to prepare yourself physically, you’re only setting yourself up for failure.
BUD/S students rush to get their inflatable boats to the finish line during a surf passage evolution. BUD/S students must endure 27 weeks of intense training in order to graduate.
(Photo by MC2 Marcos T. Hernandez)
2. It’s 80% mental
Upon arrival, students get some tips and tricks on how to survive training. However, according to Phalin, all of those tips wither away as soon as you hit the freezing surf of the Pacific ocean. The motivation to earn the Trident tends to die out the longer candidates spend in a pre-hypothermic state. Stay focused.
Students in BUD/S training class 279 participate in a surf passage exercise during the first phase of training at Naval Amphibious Base Coronado.
(Photo by MC2 Kyle D. Gahlau)
3. Make the training about brotherhood
The training’s intensity makes many students quickly consider quitting. However, it’s the extreme difficulty that creates an unbreakable brotherhood among those who make it through.
Sailors assigned to BUD/S Class 244 focus on their instructor as learn about their next training evolution.
(Photo by Photographer’s Mate 3rd Class John DeCoursey)
4. Wait five more minutes
When you think you can’t deal with the physical exhaustion any longer, convince yourself to push on for just five more minutes. Before you know it, those small 5-minute segments will add up and, suddenly, that evolution is completed. You’re one step closer to earning that beloved Trident.
Marine Corps Gen. Joe Dunford reiterated on Nov. 17, 2018, that reconciliation is the only way forward in Afghanistan and that political, economic, religious, and military pressure must be maintained on the group.
The chairman of the Joint Chiefs of Staff emphasized to Yalda Hakim, a foreign correspondent of BBC World News, that there is no military solution in Afghanistan and that the struggle in that country will require all aspects of government.
The chairman was participating in a Halifax Chat as part of the 10th annual International Security Forum here.
“Success in Afghanistan is an Afghan-owned, Afghan-led reconciliation process,” Dunford said. “That requires us to have political pressure, social pressure and military pressure. In the military dimension, our task is to make sure the Taliban realize that they cannot win on the battlefield.”
NATO and partner nations are working closely with Afghan national security forces to keep the pressure on the Taliban. At the same time, other agencies are working to improve economic conditions in the country. In addition, Islamic organizations are working to encourage the Taliban to talk with and ultimately join the Afghan government. Religious leaders in Saudi Arabia, Indonesia and Pakistan have issued fatwas calling on the Taliban to lay down their weapons and talk peace, Dunford said.
Marine Corps Gen. Joe Dunford, chairman of the Joint Chiefs of Staff, is interviewed by BBC World News correspondent Yalda Hakim in Canada during the Halifax International Security Forum in Canada, Nov. 17, 2018.
(DOD photo by Navy Petty Officer 1st Class Dominique A. Pineiro)
Part of the pressure was the recent elections in Afghanistan. “The elections that just took place, [were] largely successful and less violent, certainly, than people predicted,” he said. “And I think political transition in 2019 will also be critical in putting pressure on the Taliban.”
All this will combine to convince Taliban leaders that their future lies with reconciliation, the general said.
“But the key to success is to combine all of that pressure to incentivize the Taliban for, again, that Afghan-owned, Afghan-led reconciliation process,” he said.
Undergirding everything in Afghanistan is the South Asia Strategy. A key provision in that is its conditions-based approach. The Afghan government and Afghan people know that the world is with them in trying to move through this constant state of war. “And I would also say that the decision by NATO and partner nations to support the Afghan national defense security forces through 2024 absolutely affects the Taliban’s calculus,” Dunford said.
This article originally appeared on the United States Department of Defense. Follow @DeptofDefense on Twitter.
Second only to child custody, alimony is one of the most contentious and difficult-to-navigate processes in any divorce. When two people are splitting up, particularly when that split is acrimonious, the last thing either of them wants to discuss is the prospect of giving money to each other.
But, the topic has to be dealt with and the only way to do it successfully is to go in armed with as much knowledge as possible.
“Alimony is one of the very last pieces to fall into place,” says Lili Vasileff founder and President of Wealth Protection Management and of Divorce and Money Matters LLC and the author of Money Divorce: The Essential Roadmap To Mastering Financial Decisions. “Everything else happens and that’s the last piece of the puzzle that completes the whole picture and it’s usually the most complicated and complex because it’s interdependent on so many other things.”
It helps, adds Vasileff, to really go into this with realistic expectations because, by the time you’re negotiating alimony, you should have a very good idea of what all the other elements are as you close out this deal. Vasileff, who has decades of experience walking clients through alimony, offered these best practice tips for negotiating alimony.
1. Know your finances
One of the most important things, per Vasileff, to know when entering into alimony negotiations is what it actually costs for you to live — to understand what you can get by on, what you can’t live without, and what you’d love to have. By knowing that range, she says, you can negotiate from a better place of understanding in terms of what you might be accepting or even giving up.
Additionally, she says to have an idea of your own earning capacity. “Often I’m working with individuals who are perhaps out of the workforce permanently or temporarily or not fully employed and there’s a fear factor in not knowing what you’re able to attract in terms of your own capabilities,” she says. “And it’s really a great time to at least think about it and plan of how you need to be financially independent more or less at some point in your own life and what does that mean?”
2. Study the law
Take the time to learn all of the ins and outs of the laws in your state and how they apply to alimony payments. There are many different types of alimony out there and doing the research as to what you can realistically ask for in your state will not only help you build your case but also help you manage expectations. “If you’re expecting lifetime alimony and, let’s just say there’s a rule of thumb that it’s half the length of your marriage,” says Vasileff, “you could be in for a really bad surprise and be unable to negotiate without that kind of knowledge.”
3. Know your budget
You’re going to be paying retainers and attorney fees, so make sure that you actually have the resources available to make those payments on time. “Attorneys are not sympathetic and do not work for free often,” Vasileff says. Additionally, as you begin preparations for your divorce, make sure you figure out a budget. It’s an expensive process and going into it without a plan can set you up for a problem down the line. “Everybody plans for weddings or a bar mitzvah or a cruise,” Vasileff says. “Very few people budget for a divorce and you need to understand that there is a cost to divorce and it helps to think about it ahead of time so that you’re not taken by surprise and unprepared.”
4. Manage your expectations
While every state has uniform guidelines for child support, very few states have such guidelines when it comes to alimony. “It’s very discretionary,” Vasileff says. “It’s weighted by certain factors and the factors are enumerated in case law and in legal statutes. But how you apply those factors results in very different outcomes.”
An example from Vasileff: “Let’s be happy and say we have million and we’re going to divide million between the two of us. I could probably live off of the interest on million, which then kind of impacts what kind of alimony I receive because it’s taken into consideration. However, if we have 0,000 in debt, no savings and we’re paycheck people, alimony becomes even more critical as an element in this calculation. It’s case specific.”
5. Plan for contingencies
“If you’re dependent for the moment on your other spouse supporting you, you need to make sure that you’ve planned for contingencies, that you have an emergency fund in case something happens and you don’t receive support for that month or six months or if he or she falls off the face of the earth,” says Vasileff. You also want to make sure that their obligations to you are secured in case they die or something unforeseen happens. Vasileff stresses that it’s important to protect yourself against any unwanted surprises.
6. Think twice before waiving alimony
In some divorce cases, one party may choose to waive alimony, figuring that they’re earning enough on their own that they don’t need anything from their ex to get by. However, Vasileff suggests that keeping the door open slightly, even with a small amount like a dollar year, allows for renegotiation if something catastrophic happens. “If you have waived alimony, it is waived forever,” she notes. “The door has closed and you can never go back for support under any circumstances. So waiving alimony is a huge deal. There are reasons to waive alimony, but for the average person who’s on a paycheck, I would think twice about it.”
7. Don’t agree to anything out of court
Once the alimony is finalized in a judgment, one party cannot change it unilaterally and decide that, for example, they’re now only going to pay once every other month. A decision like that can only be made by going back to court. However, some couples might come to some kind of a handshake agreement and allow one partner to skip a payment here and there. This is something Vasileff advises against because of the slippery slope it leads to. “What if it becomes routine behavior?” she asks. “‘This month I don’t want to pay you but I’ll pay you in three months as a catchup.’ And then in three months they go on a vacation while you’re waiting for your check. Once you start to slip and allow that and enable it, it’s much harder to enforce.”
8. Keep emotion out of it
The notion of taking someone for “everything they’ve got” in court has become a cliche in divorce-related conversations, but the truth is, you don’t want to approach an alimony negotiation with anything like malice or greed, as it’s only going to fuel more negatively. “You’re telling me you’re going to go after everything I have and go for my jugular. What do you think I’m going to do?” Vasileff says. “I’m going to strike back. You need to come back to, ‘How does this transaction get executed and what’s in my best interests to make that happen?'”
9. Do your homework
Even if you think you’ve read everything there is read about alimony, read more, and then read it again. The better prepared you are, the less likely you are to be tripped up by something unexpected. “Preparation is the best defense you can possibly have. Because managing expectations will save you money, it’s going to save you in legal costs, therapy costs, everything. And it sets the tone for you to understand that it’s a process. It’s not a sprint. It’s going to be a marathon. And you’re going to have to last and preserve your energy at different points in time.”
This article originally appeared on Fatherly. Follow @FatherlyHQ on Twitter.
Ohio is home for Hillary O’Connor Mueri. She was born in Parma and moved to Painesville at three years old. She’s a graduate of Ohio State University and entered the Navy as a Buckeye ROTC midshipman in 1996.
To her, it made perfect sense to run for Congress at home, in Ohio’s 14th Congressional District. And she believes she has the perfect resume for it.
“This is where I’m from,” she told Military.com. “This is where I call home. My parents still live in the house I grew up in.”
Hillary O’Connor Mueri
But running in her home district also opens her up to intense media scrutiny in front of her lifelong friends and family. With the election still nine months away, she’s already seen her opponent and his allies come out hard against her in local media. Like many veterans, she presses on, confident in her abilities. She never thought this would be easy, she says.
“Growing up, I always thought that politics was something wealthy people did. So it was never, you know, an ambition of mine,” she explains. “And I think we really need to change that narrative. We need to make the House for the people again, to make this something that everyone can aspire to.”
That aspiration is just one reason Mueri, a lawyer and former naval flight officer, decided to run for Congress. She felt a desire to serve early in her adult life, while studying aviation engineering. She wanted to use her love for all things aircraft to serve her country, especially after realizing she’d rather be flying planes than building them, she says.
Her grandfathers were both in the Navy, but they died before she was born. Still, the tradition of service, and the Navy in particular, resonated with Mueri. For her, landing on aircraft carriers meant she could always fly on the cutting edge of aviation technology.
“Tomcats forever. First love,” she says. “All the other aircraft have amazing characteristics, but there’s something about the F-14 that’s just gonna stick with me.”
Her career took her to train in Pensacola and to the carrier Theodore Roosevelt. In 2003, she flew Strike Coordination and Reconnaissance missions supporting ground troops in northern Iraq from the Roosevelt. She later became an instructor at what was then the Naval Strike and Air Warfare Center’s (now known as Naval Aviation Warfighting Development Center) Strike school at Nevada’s Naval Air Station Fallon.
She left the Navy in 2007 with the rank of Lieutenant after getting engaged to her future husband, Simon Mueri. When he was transferred to San Diego, she went too. While there, she struggled with finding meaningful work as a civilian and decided to go to law school. Graduating in 2010, she was hired by the prestigious firm of Perkins Coie in Los Angeles.
Eventually, it was time to move home to be near her family in Ohio. But running for office wasn’t her first thought. She saw an ad for Emily’s List, a reproductive rights organization that supports women running for office. There was something about the idea of running that stuck with Mueri the same way the Tomcat did.
“Watching how chaotic our government has gotten, how it turned from service and lawmaking into partisan bickering, I couldn’t sit on the sidelines anymore,” she said. “In the military, we talk about the Constitution and how service is so valuable. I want to bring that back to the House. The House of Representatives is the people’s house, and I want to be able to affect real change for everyday people.”
Part of that dedication to service is why she thinks more veterans should run for office. She believes veterans have a “country first, mission first” outlook that drives them from day to day, regardless of political party.
“It’s about identifying what needs to get done and getting it done,” she said. “So you learn how to work as a team and ignore the distinctions between you. I think having more veterans with that perspective focused on the greater good, instead of about the petty day-to-day things, we’re going to be able to really accomplish a lot that is solely for the benefit of the country.”
But it isn’t easy. Running for office is almost a 24/7 job, with nearly limitless pulls on the candidate’s attention. Being a veteran is also good preparation for those problems, she says. The 24/7 mentality is strong with most military members, and the demands of military life are great practice for balancing priorities. What most veterans probably aren’t prepared for is suddenly being in the spotlight.
“Suddenly, you have to realize that there will be a larger amount of attention paid to what you do, as opposed to going about your everyday life,” Mueri said. “That takes some getting used to.”
In her situation, allegations were made by the Ohio Republican Party that, while she was transitioning to civilian life and moving from Nevada to California in 2008, she requested an absentee ballot from the state of Ohio and voted in two primary elections.
“You’re very exposed,” she said. “It’s shocking to see that sort of thing sprung on you. In the end, you have to let it roll off your back and keep moving forward as long as you have the truth on your side. And I do, so I just have to carry on being myself.”
Researchers have identified a compound that blocks the spread of pancreatic and other cancers in various animal models. When cancer spreads from one part of the body to another in a process called metastasis, it can eventually grow beyond the reach of effective therapies. Now, there is a new plan of attack against this deadly process, thanks to scientists at the National Institutes of Health, Northwestern University and their collaborative research partners.
The team collaborated to identify a compound, which they named metarrestin, that stopped tumor metastasis in multiple animal models. Mice treated with metarrestin also had fewer tumors and lived longer than mice that did not receive treatment. These results were published May 16, 2018, in Science Translational Medicine.
In patients, metarrestin potentially could be effective as a therapy after cancer surgery. Because advanced cancers are difficult to completely remove with surgery, doctors typically give chemotherapy to try to kill undetected cancer cells left behind and prevent the cancer from coming back. Metarrestin could be added to such standard drug therapy.
Metarrestin breaks down an incompletely understood component of cancer cells called the perinucleolar compartment (PNC). PNCs are found only in cancer cells, and in a higher number of cells in advanced cancer, when it has spread to other sites in the body.
Co-author Sui Huang, M.D., Ph.D., and her colleagues at Northwestern University Feinberg School of Medicine, Chicago, showed early on that the more cancer cells with PNCs in a tumor, the more likely it would spread. Her findings suggested that reducing PNCs might translate to less cancer progression and possibly better outcomes in patients.
To test these ideas, Huang approached Marugan to tap into NCATS’ expertise in screening, chemistry, compound development and testing to evaluate more than 140,000 compounds for their potential effectiveness in eliminating PNCs in cells in advanced cancer.
While nearly 100 compounds initially showed some activity, the investigators identified one compound that could effectively break down PNCs in advanced prostate cancer cells. With the help of researchers at the University of Kansas, Lawrence, they modified the compound to make it work better as a potential drug and evaluated the effects of the molecule in different assays, or tests, in the laboratory. They found that metarrestin could block the way prostate and pancreatic cancer cells spread.
In collaboration with co-author Udo Rudloff, M.D., Ph.D., from NIH’s National Cancer Institute’s (NCI) Center for Cancer Research, the group evaluated the effects — including toxicity — of metarrestin in pancreatic cancer mouse models. The investigators found that it prevented the further spread of pancreatic cancer by disrupting the protein-making machinery of cancer cells, and mice treated with metarrestin lived longer than mice without treatment.
“Cancer cells are rapidly dividing and need to make more proteins than healthy cells to help carry out various activities, including the ability to spread,” Rudloff said. “Interfering with the system stalls cancer cell metastasis.”
Rudloff and his NCI group currently are working with scientists at the NCATS-led Bridging Interventional Development Gaps program to collect the pre-clinical data on metarrestin needed to further its development as a candidate drug. The scientists plan to file an Investigational New Drug (IND) application in the fall with the U.S. Food and Drug Administration (FDA). FDA IND approval is necessary before a candidate drug can be tested in patients.
The research was funded by NCATS and NCI through their intramural programs, and in addition, the National Human Genome Research Institute grant U54HG005031, the National Institute of General Medical Sciences grants R01GM078555 and R01GM115710, NCI grant 2 P30 CA060553-19, the V Foundation, a donation from the Baskes family to the Robert H. Lurie Comprehensive Cancer Center, donations from ‘Running for Rachel’ and the Pomerenk family via the Rachel Guss and Bob Pomerenk Pancreas Cancer Research Fellowship to NCI, the Robert H. Lurie Comprehensive Cancer Center – Translational Bridge Program Fellowship in Lymphoma Research and the Molecular Libraries Initiative funding to the University of Kansas Specialized Chemistry Center.
About the National Center for Advancing Translational Sciences (NCATS): NCATS conducts and supports research on the science and operation of translation — the process by which interventions to improve health are developed and implemented — to allow more treatments to get to more patients more quickly. For more information about how NCATS is improving health through smarter science, visit https://ncats.nih.gov.
About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit www.nih.gov.
This past week was a special anniversary for Americans.
We observed the 75th anniversary of the battle of Iwo Jima, and specifically, on Feb. 23, we honored the 75th anniversary of the raising of the flag and the immortal photo taken by Joe Rosenthal.
Around the country, there were special celebrations to honor the men who served in that ferocious and terrible battle. Many politicians, notable figures and average Joe’s took to social media to honor the men who fought and died on Iwo.
With the passage of time, there are fewer and fewer men who fought on the volcanic rock, so events honoring them get more and more special.
Medal of Honor recipient Woody Williams was honored at a Washington Capitals game over the weekend. Williams, who earned Medal of Honor as a flamethrower on Iwo Jima, was showered with applause and adulation by the Capitals fans, players and members of the opposing team, the Pittsburgh Penguins. Williams is the last recipient living of the 27 men who were awarded the Medal of Honor for bravery during Iwo Jima.
Watch Williams being honored at the game:
Williams took to Twitter (yes, Medal of Honor Iwo Jima vets have Twitter too) to express his excitement of being at the game.
Williams, aged 96, shows no sign of stopping. He will be giving a TEDx talk this March at Marshall University.
While many other events took place around the country, a very special commemoration took place in California.
Twenty-eight Iwo Jima veterans and members of the Iwo Jima Commemorative Committee posae for a picture after an event commemoratiing the 75th annivesary of the World War II Battle of Iwo Jima at Marine Corps Base Camp Pendleton, Calif., on Saturday, Feb. 15, 2020.
Camp Pendleton hosted a reunion of over two dozen Iwo Jima veterans last week. Over the course of three days, the Iwo Jima Commemorative Committee held events on Pendleton to honor the men that fought there. Sadly, the Marine Corps put out a statement saying that this would probably be the last formal event as fewer and fewer veterans are alive and in shape to travel.
But as they say, tell that to the Marines.
“It’s very special to be a part of this ceremony,” said William “Bill” Wayne, an Iwo Jima veteran whose fellow Marines of Easy Company, 2nd Battalion, 28th Marines, 5th Marine Division, raised the flag on Mount Suribachi. “I get a real kick out of coming and seeing everyone and talking to the young Marines.”
Mylee Cardenas had a plan: stay in the Army until they told her to leave. But her dreams of becoming a career soldier were derailed by cancer. Instead, she found her second wind in life as a model and actress.
Without any money in the family to afford college, Mylee had intended to use the military to become a doctor, joining at seventeen as soon as she finished high school. Once she was in, however, her plan quickly changed to be a career soldier. She deployed to Northern Afghanistan, where her unit was responsible for all nine provinces in the region. However, while she was there, things changed.
When she was diagnosed with Stage III breast cancer, she had every intention of defeating it and throwing herself straight back into the fight. The medical board reviewing her case had other ideas. After a lengthy process, she was declared unfit for duty, and retired due to both the breast cancer and severe combat-related PTSD.
She lost her uniform, which she considered her shield and strength overnight, but she gained so many new opportunities. Through motivational speaking, she was able to inspire people, especially veterans, around the country with her story. She now models, acts, and is a fitness coach on the side while she goes to school in the hopes of becoming a physical therapist.
Although she still comes home with the muscle memory of waiting for a phone call telling her she can return to duty, she now has other plans in place. While her circumstances of leaving the military were sad, she also came out with the feeling of suddenly being free.
Brigadier General Carl Schaefer, the commander of the 412th Test Wing, put the endless speculation as to where the B-21 would be heading to rest during comments at the Antelope Valley Board of Trade and Business Outlook Conference, according to The Drive.
“For the first time ever, I would like to publicly announce that the B-21 will be tested at Edwards Air Force Base … Edwards has been the home of bomber test and now we also can publicly release that the B-21 is coming to Edwards and we will be testing it here in the near future,” Schaefer said.
The general’s remarks appeared to confirm that the B-21 will be headed for operational testing sooner than some had previously believed. There are no known images of the B-21, although concept art does exist.
The level of secrecy surrounding the B-21 is so intense that Congress doesn’t even know much about it. Previous reports speculated that the testing would be at the Air Force’s infamous Area 51 facility.
The Drive reporter Tyler Rogoway said that he noticed a number of changes to the base during his last visit to Edwards. “It was clear that the South Base installation was undergoing a major transition,” he said.
“The USAF’s B-52 and B-1 bomber test units had relocated to the expansive primary apron and South Base had been vacated, aside from the B-2 test unit, so that it could be prepared for a shadowy new program.”
Edwards Air Force Base has unique facilities that would help the testing and development of stealth aircraft, such as the Raider, and is the headquarters of the Air Force’s Test Center and Test Pilot School. Edwards is also the home of NASA’s Armstrong Flight Research Center.
The B-21 will phase out the B-1 and B-2 bombers, the Air Force announced in February 2018.